This white paper discusses design challenges and solutions related to the "third wave" of communications, presenting several case studies in which the Cadence® AWR Design Environment® platform has been used to develop products for 5G and beyond. Examples include a multiband active antenna tuner for cellular internet of things (IoT) machine-type communications (mMTC) applications, a linear power amplifier (PA) design flow to address enhanced mobile broadband (eMBB) communications in the sub-6GHz bands, and a 5G mmWave (28GHz) reference design being developed by Cadence with multiple design tools for a complete chip, package, board, and antenna design serving 5G fixed wireless access (FWA) application.